research +

Targeted in chronic and undertreated pathologies of high prevalence.

development +

New generation of dietary foods for more effective treatments.

innovation and licensing +

We already have more than 80 patents and licenses of international marketing. All our nutraceuticals products have log category of Food for Special Medical Purposes.


We are a Biomedical Company specialized in Medical Nutrition,

founded in 2007 in Barcelona (Spain), we develop activities of research, development, innovation, marketing and licensing-out of new nutraceuticals and functional foods.

Our great value is the investigation and we firmly believe in the alliance between “Company-University”. We have two R&D&i centers. 

From our production plant we offer our nutraceuticals products in different gastro-resistant formats (tablets, pellets, micropellets, capsules, microcapsules and nanocapsules), facilitating the adaptation to the current regulations of each market and their marketing on an international scale.

We also develop In Vitro molecular diagnostic kits. 

specialists in the DAO deficit

DAO deficiency is an alteration in the metabolism of food histamine that occurs when there is little activity of the enzyme diamine oxidase (DAO). The DAO is the main enzyme in the metabolism of exogenous histamine and begins its functional activity in the intestine.

When exists a disproportion between the histamine swallowed or released by the cells that store it in the body, and the ability to metabolize it, there is the accumulation of histamine in plasma and the appearance of adverse effects.

A deficit in the metabolic activity of diamine oxidase can be due to genetic, pharmacological and pathological factors.

main symptoms in DAO DEFICIT

Migraine, fibromyalgia, irritable bowel syndrome (IBS) and the attention deficit-hyperactivity disorder (ADHD) are the symptoms with higher prevalences in the world population caused by DAO deficiency.


millions of people affected by ADHD

% of the population with ADHD is also affected of deficit of DAO

millions of people affected by migraine

% of the population with migraine is also affected of deficit of DAO

millions people affected by fibromyalgia

% of the population with fibromyalgia is also affected of deficit of DAO

millions of people affected by Irritable Bowel Syndrome

% of the population with Irritable Bowel Syndrome is also affected of deficit of DAO

Actuality about deficit of dao

News in media and press releases

Can you be allergic to alcohol? –

Published on 28-3-2019 – – Language: Spanish. From the Spanish Society of Allergology and Clinical Immunology (SEAIC), Dr. Pedro Ojeda in an interview to the Media Infosalus indicates that there is a clinical non allergic picture, hereinafter referred to as ” non-allergic histaminosis” or “DAO deficiency”, in...

Clinical evidence and scientific publications 

Serum levels of histamine and diamine oxidase in multiple sclerosis

Serum levels of histamine and diamine oxidase in multiple sclerosis Download pdf   Am J Clin Exp Immunol 2018;7(6):100-105 /ISSN:2164-7712/AJCEI0086352 Aryan Rafiee Zadeh1, Masih Falahatian1, Fereshteh Alsahebfosoul2 1School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; 2Department of Immunology, School of Medicine, Isfahan University...


Are underestimated the amounts of biogenic amines in diets low in histamine ?

  Diets low in histamine are currently used to reduce symptoms of intolerance to histamine, a disorder in the homeostasis of this molecule that increases its blood levels, due mainly to the reduction of the activity of the diamine oxidase (DAO) enzyme. In fact, these diets low in histamine exclude foods, many of them of plant origin, that patients associate with the...